AN UNBIASED VIEW OF CONOLIDINE ALKALOID FOR CHRONIC PAIN

An Unbiased View of Conolidine alkaloid for chronic pain

Though the opiate receptor depends on G protein coupling for signal transduction, this receptor was observed to benefit from arrestin activation for internalization with the receptor. Otherwise, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable advancement in binding efficacy. This binding

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